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Vincent C O Njar Selected Research

4-(1H-imidazol-1-yl)retinoic acid

7/2014VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.
5/2012Anti-tumor effects of a novel retinoic acid metabolism blocking agent VN/14-1 in the N-methyl-N-nitrosourea-induced rat mammary carcinoma model and its effects on the uterus.
3/2008Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.
11/2007Murine toxicology and pharmacokinetics of novel retinoic acid metabolism blocking agents.
12/2006Effects of novel retinoic acid metabolism blocking agent (VN/14-1) on letrozole-insensitive breast cancer cells.
12/2004Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.

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Vincent C O Njar Research Topics

Disease

39Prostatic Neoplasms (Prostate Cancer)
01/2022 - 06/2003
26Neoplasms (Cancer)
01/2022 - 10/2004
9Breast Neoplasms (Breast Cancer)
07/2014 - 12/2004
4Neoplasm Metastasis (Metastasis)
03/2019 - 04/2010
2Triple Negative Breast Neoplasms
03/2019 - 01/2014
2Disease Progression
08/2017 - 01/2008
1Myeloproliferative Disorders (Myeloproliferative Disorder)
11/2020
1Pancreatic Neoplasms (Pancreatic Cancer)
08/2017
1Carcinogenesis
05/2017
1Carcinoma (Carcinomatosis)
05/2012
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
07/2006
1Acute Promyelocytic Leukemia
07/2006
1Acne Vulgaris
07/2006
1Skin Neoplasms (Skin Cancer)
07/2006
1Kaposi Sarcoma (Kaposi's Sarcoma)
07/2006
1Psoriasis (Pustulosis Palmaris et Plantaris)
07/2006

Drug/Important Bio-Agent (IBA)

15Androgen Receptors (Androgen Receptor)IBA
01/2018 - 10/2006
15AndrogensIBA
10/2017 - 06/2003
9Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
05/2011 - 10/2004
83- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- dieneIBA
01/2022 - 06/2013
8Tretinoin (Retinoic Acid)FDA LinkGeneric
08/2012 - 12/2004
7Pharmaceutical PreparationsIBA
10/2019 - 10/2004
6Eukaryotic Initiation Factor-4EIBA
03/2019 - 01/2014
64-(1H-imidazol-1-yl)retinoic acidIBA
07/2014 - 12/2004
6Hormones (Hormone)IBA
07/2008 - 10/2004
5Proteins (Proteins, Gene)FDA Link
01/2018 - 04/2008
4Phosphotransferases (Kinase)IBA
03/2019 - 10/2006
4Biological ProductsIBA
11/2011 - 12/2004
3Mitogen-Activated Protein KinasesIBA
03/2019 - 12/2006
3Aromatase InhibitorsIBA
07/2014 - 12/2006
3Estrogens (Estrogen)FDA Link
05/2012 - 12/2006
3EnzymesIBA
04/2010 - 08/2007
3ProdrugsIBA
04/2010 - 08/2007
3Androgen Antagonists (Antiandrogens)IBA
08/2008 - 04/2005
3bicalutamide (Casodex)FDA LinkGeneric
08/2008 - 10/2004
2abirateroneIBA
01/2022 - 11/2011
2enzalutamideIBA
01/2022 - 10/2019
2Therapeutic UsesIBA
10/2019 - 01/2018
2VimentinIBA
01/2018 - 11/2016
2Matrix Metalloproteinases (MMPs)IBA
01/2018 - 11/2016
2Cyclin D1IBA
01/2018 - 12/2006
2Cadherins (E-Cadherin)IBA
01/2018 - 11/2016
2Peptide Initiation Factors (Initiation Factor)IBA
05/2017 - 01/2014
2VNPT55IBA
11/2016 - 09/2015
2Aromatase (CYP19)IBA
07/2014 - 08/2007
2Letrozole (Femara)FDA LinkGeneric
07/2014 - 12/2006
2Chloroquine (Aralen)FDA LinkGeneric
08/2012 - 04/2012
2Estrogen ReceptorsIBA
05/2012 - 12/2006
2Abiraterone AcetateIBA
11/2011 - 05/2011
2Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
04/2010 - 08/2007
2Mixed Function Oxygenases (Monooxygenases)IBA
09/2008 - 08/2008
2Histone Deacetylase InhibitorsIBA
07/2008 - 03/2008
2RetinoidsIBA
03/2008 - 07/2005
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2006 - 10/2006
1RNA (Ribonucleic Acid)IBA
01/2022
1Mechanistic Target of Rapamycin Complex 1IBA
03/2019
14- (+;- )- (1H- imidazole- 1- yl)- N- (4- fluorophenyl)- (E)- retinamideIBA
03/2019
1ChemokinesIBA
03/2019
1CytokinesIBA
03/2019
1ClaudinsIBA
01/2018
1CateninsIBA
01/2018
1retinamideIBA
01/2018
1Prostate-Specific Antigen (Semenogelase)IBA
01/2018
1Dihydrotachysterol (AT 10)IBA
01/2018
1LigandsIBA
10/2017
1GemcitabineFDA Link
08/2017
1Messenger RNA (mRNA)IBA
11/2016
1Ether (Diethyl Ether)IBA
07/2016
1Cytochromes c (Cytochrome c)IBA
09/2015
1ThapsigarginIBA
07/2014
1Methylnitrosourea (N-Methyl-N-nitrosourea)IBA
05/2012
1Estradiol (Delestrogen)FDA LinkGeneric
05/2012
1Ketoconazole (Nizoral)FDA LinkGeneric
05/2011
1orteronelIBA
05/2011
1AntioxidantsIBA
04/2010
1PhytochemicalsIBA
04/2010
1Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
04/2010
13beta- hydroxy- 17- (1H- benzimidazole- 1- yl)androsta- 5,16- dieneIBA
08/2008
1Isotretinoin (Accutane)FDA LinkGeneric
03/2008
1theasinensin AIBA
03/2008
1entinostat (MS 275)IBA
03/2008
1tacedinaline (CI 994)IBA
03/2008
1Androgen Receptor AntagonistsIBA
01/2008
1CytochromesIBA
12/2007
1dehydroepiandrosterone acetateIBA
12/2007
1Vitamin A (Retinol)FDA LinkGeneric
08/2007
1Cholecalciferol (Vitamin D3)FDA Link
08/2007
1Estrogen Receptor alphaIBA
12/2006
1TamoxifenFDA LinkGeneric
12/2006
1src-Family KinasesIBA
10/2006
1Tyrosine (L-Tyrosine)FDA Link
10/2006
1VorinostatFDA Link
07/2005
1Histone Deacetylases (Histone Deacetylase)IBA
07/2005
1E 10 (E-10)IBA
04/2005
1Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
12/2004
1Growth InhibitorsIBA
12/2004
1Carboxylic AcidsIBA
12/2004

Therapy/Procedure

16Therapeutics
11/2020 - 06/2003
13Castration
01/2022 - 10/2004
2Chemoprevention
04/2010 - 08/2007